With many regular donors taking time off during the holiday season, Lifeblood spokesperson Nicky Breen said more 'Secret Santas' are needed.

"Seventy-three donors are needed to prevent a possible shortage of blood stocks vital to the treatment of cancer patients," Ms Breen said.

"With many people taking time off this holiday season we need those who can to step up and be a life-changing 'Secret Santa' to Australian patients in need, ensuring no one misses out on receiving this incredible gift.

"If Secret Santa is about giving anonymous gifts designed to make someone's day, then blood donation really is Australia's ultimate Secret Santa exchange."

After they donate, donors will be given a card to give to someone special to tell them they gave blood on their behalf.

Blood will be needed by road accident patients, pregnant mums, cancer patients and premature babies every day of the Christmas and New Year period.

Ms Breen said stock of platelets were particularly at risk.

"It takes four blood donations to make just one bag of platelets for patients and they only last for five days so donors are constantly needed to ensure cancer patients get this vital product," Ms Breen said.

"Your blood donation will be the ultimate gift to Australian patients this Christmas - and will have a far-reaching impact on the lives you save, and the lives of their loved ones.

"So this Christmas we're urging Taree locals to take part in Australia's Biggest Secret Santa exchange by making an appointment to give blood between December 16 and January 6."

A new donor is needed every five minutes to meet Australia's growing blood needs.

The Lifeblood Taree Donation Centre will be open on Christmas Eve and New Year's Eve between 8am and 2pm.

The centre will be closed on Christmas Day, Boxing Day and New Year's Day.

To make an appointment, call 13 14 95 or visit www.lifeblood.com.au.